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Nucleic Acids Research, 1993, Vol. 21, No. 8 1687-1688
© 1993

SURVEY AND SUMMARY

A rational nomenclature for vertebrate homeobox (HOX) genes

Matthew P. Scott

Departments of Developmental Biology and Genetics, Stanford University School of Medicine Stanford, CA 94305-5427, USA

Received January 21, 1993. Accepted March 5, 1993.

Developmental fates along the anterior-posterior axes of animals are controlled by clustered homeotlc genes which In vertebrates are called Hox genes. The gene clusters are similar and probably functionally homologous in animals as different as nematodes, files, and mammals. A new set of names for Hox genes was recently agreed upon by many workers In the field. Remarkably, the order of the Hox genes along the chromosome reflects where they are expressed along the body axis1. This simple principle is reflected in the new nomenclature system.


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