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Nucleic Acids Research, 2000, Vol. 28, No. 1 369-371
© 2000 Oxford University Press

KinMutBase, a database of human disease-causing protein kinase mutations

Kaj A. E. Stenberg1, Pentti T. Riikonen2,3 and Mauno Vihinen2,*

1Department of Biosciences, Division of Biochemistry, PO Box 56, FIN-00014 University of Helsinki, Finland, 2Institute of Medical Technology, University of Tampere, PO Box 607, FIN-33101 Tampere, Finland and 3Department of Computer Science, University of Turku, Lemminkäisenkatu 14A, FIN-20520 Turku, Finland

KinMutBase (http://www.uta.fi/imt/bioinfo/KinMutBase/ ) is a registry of mutations in human protein kinases related to disorders. Kinases are essential cellular signaling molecules, in which mutations can lead to diseases, including immunodeficiencies, cancers and endocrine disorders. The first release of KinMutBase contained information for protein tyrosine kinases. The current release includes also serine/threonine protein kinases, as well as an update of the tyrosine kinases. There are 251 entries altogether, representing 337 families and 621 patients. Mutations appear both in conserved hallmark residues of the kinases as well as in non-homologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics and display, clickable sequences with mutations and changes to restriction enzyme patterns.

* To whom correspondence should be addressed. Tel: +358 3 215 7735; Fax: +358 3 215 7710; Email: ltmavi@uta.fi


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