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Nucleic Acids Research, 2002, Vol. 30, No. 1 218-220
© 2002 Oxford University Press

The human (PEDB) and mouse (mPEDB) Prostate Expression Databases

Peter S. Nelson1,2,*, Colin Pritchard1, Denise Abbott1 and Nigel Clegg1

1Division of Human Biology and 2Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109-1024, USA

The Prostate Expression Databases (PEDB and mPEDB) are online resources designed to allow researchers to access and analyze gene expression information derived from the human and murine prostate, respectively. Human PEDB archives more than 84 000 Expressed Sequence Tags (ESTs) from 38 prostate cDNA libraries in a curated relational database that provides detailed library information including tissue source, library construction methods, sequence diversity and sequence abundance. The differential expression of each EST species can be viewed across all libraries using a Virtual Expression Analysis Tool (VEAT), a graphical user interface written in Java for intra- and inter-library sequence comparisons. Recent enhancements to PEDB include (i) the development of a murine prostate expression database, mPEDB, that complements the human gene expression information in PEDB, (ii) the assembly of a non-redundant sequence set or ‘prostate unigene’ that represents the diversity of gene expression in the prostate, and (iii) an expanded search tool that supports both text-based and BLAST queries. PEDB and mPEDB are accessible via the World Wide Web at http://www.pedb.org and http://www.mpedb.org.

* To whom correspondence should be addressed at: Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109-1024, USA. Tel: +1 206 667 3377; Fax: +1 206 667 2917; Email: pnelson{at}fhcrc.org


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