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Nucleic Acids Research, 2003, Vol. 31, No. 13 3352-3355
© 2003 Oxford University Press

CASTp: Computed Atlas of Surface Topography of proteins

T. Andrew Binkowski, Shapor Naghibzadeh and Jie Liang*

Department of Bioengineering, MC-063, University of Illinois at Chicago, 851 S. Morgan Street, Chicago, IL 60607, USA

*To whom correspondence should be addressed. Tel: +1 3123551789; Fax: +1 3129965921; Email: jliang{at}uic.edu

Computed Atlas of Surface Topography of proteins (CASTp) provides an online resource for locating, delineating and measuring concave surface regions on three-dimensional structures of proteins. These include pockets located on protein surfaces and voids buried in the interior of proteins. The measurement includes the area and volume of pocket or void by solvent accessible surface model (Richards' surface) and by molecular surface model (Connolly's surface), all calculated analytically. CASTp can be used to study surface features and functional regions of proteins. CASTp includes a graphical user interface, flexible interactive visualization, as well as on-the-fly calculation for user uploaded structures. CASTp is updated daily and can be accessed at http://cast.engr.uic.edu.


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