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Nucleic Acids Research 2006 34(Web Server issue):W15-W19; doi:10.1093/nar/gkl254
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Article

The MIGenAS integrated bioinformatics toolkit for web-based sequence analysis

Markus Rampp*, Thomas Soddemann and Hermann Lederer

Rechenzentrum Garching der Max-Planck-Gesellschaft (RZG), am Max-Planck-Institut für Plasmaphysik Boltzmannstrasse 2, 85748 Garching, Germany

*To whom correspondence should be addressed. Tel: +49 0 89 3299 2176; Fax: +49 0 80 3299 1301; Email: markus.rampp{at}rzg.mpg.de

Received February 14, 2006. Revised March 13, 2006. Accepted March 30, 2006.

We describe a versatile and extensible integrated bioinformatics toolkit for the analysis of biological sequences over the Internet. The web portal offers convenient interactive access to a growing pool of chainable bioinformatics software tools and databases that are centrally installed and maintained by the RZG. Currently, supported tasks comprise sequence similarity searches in public or user-supplied databases, computation and validation of multiple sequence alignments, phylogenetic analysis and protein–structure prediction. Individual tools can be seamlessly chained into pipelines allowing the user to conveniently process complex workflows without the necessity to take care of any format conversions or tedious parsing of intermediate results. The toolkit is part of the Max-Planck Integrated Gene Analysis System (MIGenAS) of the Max Planck Society available at www.migenas.org (click ‘Start Toolkit’).


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