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Nucleic Acids Research Advance Access originally published online on December 23, 2007
Nucleic Acids Research 2008 36(Database issue):D724-D728; doi:10.1093/nar/gkm961
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Nucleic Acids Research, 2008, Vol. 36, Database issue D724-D728
© 2007 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article appears in the following Nucleic Acids Research issue: Database issue [View the issue table of contents]

Articles

The Mouse Genome Database (MGD): mouse biology and model systems

Carol J. Bult*, Janan T. Eppig, James A. Kadin, Joel E. Richardson, Judith A. Blake and the Mouse Genome Database Group{dagger}

The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA

*To whom correspondence should be addressed. Tel: +1 207 288 6248; Fax: +1 207 288 6132; Email: carol.bult{at}jax.org

Received September 19, 2007. Revised October 14, 2007. Accepted October 15, 2007.

The Mouse Genome Database, (MGD, http://www.informatics.jax.org/), integrates genetic, genomic and phenotypic information about the laboratory mouse, a primary animal model for studying human biology and disease. MGD data content includes comprehensive characterization of genes and their functions, standardized descriptions of mouse phenotypes, extensive integration of DNA and protein sequence data, normalized representation of genome and genome variant information including comparative data on mammalian genes. Data within MGD are obtained from diverse sources including manual curation of the biomedical literature, direct contributions from individual investigator's laboratories and major informatics resource centers such as Ensembl, UniProt and NCBI. MGD collaborates with the bioinformatics community on the development of data and semantic standards such as the Gene Ontology (GO) and the Mammalian Phenotype (MP) Ontology. MGD provides a data-mining platform that enables the development of translational research hypotheses based on comparative genotype, phenotype and functional analyses. Both web-based querying and computational access to data are provided. Recent improvements in MGD described here include the association of gene trap data with mouse genes and a new batch query capability for customized data access and retrieval.

{dagger}The Mouse Genome Database Group: M.T. Airey, A. Anagnostopoulos, R. Babiuk, R.M. Baldarelli, M. Baya, J.S. Beal, S.M. Bello, D.W. Bradt, D.L. Burkart, N.E. Butler, J. Campbell, L.E. Corbani, S.L. Cousins, D.J. Dahmen, H. Dene, M.E. Dolan, K.L. Forthofer, K.S. Frazer, P. Frost, M. Hall, M. Knowlton, J.R. Lewis, I. Lu, L.J. Maltais, M. McAndrews-Hill, S. McClatchy, M.J. McCrossin, J. Mason, D.B. Miers, L.A. Miller, L. Ni, H. Onda, J.E. Ormsby, T.B.K. Reddy, D.J. Reed, B. Richards-Smith, D.R. Shaw, R. Sinclair, D. Sitnikov, C.L. Smith, P. Szauter, M. Tomczuk, M.A. Updegraff, L.L. Washburn, I.T. Witham and Y. Zhu.


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