Nucleic Acids Research, Vol 27, Issue 1 229-232, Copyright © 1999 by Oxford University Press
CP Ponting, J Schultz, F Milpetz and P Bork
SMART is a simple modular architecture research tool and database that
provides domain identification and annotation on the WWW
(http://coot.embl-heidelberg.de/SMART). The tool compares query sequences
with its databases of domain sequences and multiple alignments whilst
concurrently identifying compositionally biased regions such as signal
peptide, transmembrane and coiled coil segments. Annotated and unannotated
regions of the sequence can be used as queries in searches of sequence
databases. The SMART alignment collection represents more than 250
signalling and extracellular domains. Each alignment is curated to assign
appropriate domain boundaries and to ensure its quality. In addition, each
domain is annotated extensively with respect to cellular localisation,
species distribution, functional class, tertiary structure and functionally
important residues.
ARTICLES
SMART: identification and annotation of domains from signalling and extracellular protein sequences
University of Oxford, Fibrinolysis Research Unit, The Old Observatory, South Parks Road, Oxford OX1 3RH, UK. ponting@ncbi.nlm.nih.gov
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