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Nucleic Acids Research, 2001, Vol. 29, No. 1 33-36
© 2001 Oxford University Press

CluSTr: a database of clusters of SWISS-PROT+TrEMBL proteins

Evgenia V. Kriventseva*, Wolfgang Fleischmann, Evgeni M. Zdobnov and Rolf Apweiler

EMBL Outstation, The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK

The CluSTr (Clusters of SWISS-PROT and TrEMBL proteins) database offers an automatic classification of SWISS-PROT and TrEMBL proteins into groups of related proteins. The clustering is based on analysis of all pairwise comparisons between protein sequences. Analysis has been carried out for different levels of protein similarity, yielding a hierarchical organisation of clusters. The database provides links to InterPro, which integrates information on protein families, domains and functional sites from PROSITE, PRINTS, Pfam and ProDom. Links to the InterPro graphical interface allow users to see at a glance whether proteins from the cluster share particular functional sites. CluSTr also provides cross-references to HSSP and PDB. The database is available for querying and browsing at http://www.ebi.ac.uk/clustr.

* To whom correspondence should be addressed. Tel: +44 1223 494 430; Fax: +44 1223 494 468; Email: evgenia.kriventseva{at}ebi.ac.uk


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