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Nucleic Acids Research, 2002, Vol. 30, No. 1 349-350
© 2002 Oxford University Press

Sentra, a database of signal transduction proteins

Natalia Maltsev*, E. Marland, G. X. Yu, S. Bhatnagar and R. Lusk

Mathematics and Computer Science Division, Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL 60439, USA

Sentra (http://www-wit.mcs.anl.gov/sentra) is a database of signal transduction proteins with the emphasis on microbial signal transduction. The database was updated to include classes of signal transduction systems modulated by either phosphorylation or methylation reactions such as PAS proteins and serine/threonine kinases, as well as the classical two-component histidine kinases and methyl-accepting chemotaxis proteins. Currently, Sentra contains signal transduction proteins from 43 completely sequenced prokaryotic genomes as well as sequences from SWISS-PROT and TrEMBL. Signal transduction proteins are annotated with information describing conserved domains, paralogous and orthologous sequences, and conserved chromosomal gene clusters. The newly developed user interface supports flexible search capabilities and extensive visualization of the data.

* To whom correspondence should be addressed. Tel: +1 630 252 5195; Fax: +1 630 252 5986; Email: maltsev{at}mcs.anl.gov


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