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The imprinted gene and parent-of-origin effect database now includes parental origin of de novo mutations
Department of Biology, Massachusetts College of Liberal Arts North Adams, MA 01247, USA 1Department of Microbiology, University of Otago PO Box 56, Dunedin, New Zealand 2Department of Biochemistry, University of Otago PO Box 56, Dunedin, New Zealand
*To whom correspondence should be addressed. Tel: +1 413 662 5548; Email: rglaser{at}mcla.edu
Received September 5, 2005. Revised October 9, 2005. Accepted October 17, 2005.
The imprinted gene and parent-of-origin effect database (www.otago.ac.nz/IGC) consists of two sections. One section catalogues the current literature on imprinted genes in humans and animals. The second, and new, section catalogues current reports of parental origin of de novo mutations in humans alone. The addition of a catalogue of de novo mutations that show a parent-of-origin effect expands the scope of the database and provides a useful tool for examining parental origin trends for different types of spontaneous mutations. This new section includes >1700 mutations, found in 59 different disorders. The 85 imprinted genes are described in 152 entries from several mammalian species. In addition, >300 other entries describe a range of reported parent-of-origin effects in animals.
Correspondence may also be addressed to Ian M. Morison. Tel: +64 3 479 5391; Fax +64 3 479 7738; Email: ian.morison{at}otago.ac.nz